(4R)-4-phenyl-1,3-oxazolidin-2-one → HCID 67380840, compound

HRID 1804150

Reaction equation

HRID 1804150 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1.[C:24]1([C@@H:30]2[CH2:34][O:33][C:32](=[O:35])[NH:31]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:31]3[C@H:30]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:34][O:33][C:32]3=[O:35])=[CH:19][CH:18]=2)=[O:16])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 730425(4R)-4-phenyl-1,3-oxazolidin-2-oneHCID 58484733[4-(2,4-Dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 67380840HCID 67380840, compoundYield 9.7%

Procedure

By reaction and treatment in the same manner as in Example 1 and using [4-(2,4-dimethylphenyl)piperazin-1-yl](4-iodophenyl)methanone (841 mg) described in Preparation Example 8 and (R)-(−)-4-phenyloxazolidin-2-one (326 mg), the title compound (88 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-74d61f39dbdc458d94d4b29a0004aa1f
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Linked notes

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