2-Oxazolidinone → 3-{3-(3-Acetyl-2-oxoimidazolidin-1-yl)-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804287

Reaction equation

HRID 1804287 reaction equation
[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:32])(=[O:3])[CH3:2].[O:33]1[CH2:37][CH2:36][NH:35][C:34]1=[O:38]>>[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N:35]3[CH2:36][CH2:37][O:33][C:34]3=[O:38])[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:32])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 584846831-Acetyl-3-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one

Product 1

HCID 673809123-{3-(3-Acetyl-2-oxoimidazolidin-1-yl)-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneYield 10.2%

Procedure

By reaction and treatment in the same manner as in Example 201 and using 1-acetyl-3-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one (221.5 mg) described in Preparation Example 126 and oxazolidin-2-one (42.3 mg), the title compound (25.2 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 201

Sources & evidence

ORD record
ord-81aa1012ec014325a0bf93502b787b04
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Linked notes

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