Ethyl p-(2-oxo-1,3-oxazolidin-3-yl)benzoate → 3-{4-[4-(2,6-Dimethylpyridin-3-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804407

Reaction equation

HRID 1804407 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][CH:8]=2)[CH2:5][CH2:4][O:3]1.[CH3:18][C:19]1[C:24]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:23][CH:22]=[C:21]([CH3:31])[N:20]=1>>[CH3:18][C:19]1[C:24]([N:25]2[CH2:30][CH2:29][N:28]([C:11]([C:10]3[CH:9]=[CH:8][C:7]([N:6]4[CH2:5][CH2:4][O:3][C:2]4=[O:1])=[CH:17][CH:16]=3)=[O:13])[CH2:27][CH2:26]2)=[CH:23][CH:22]=[C:21]([CH3:31])[N:20]=1

Participants

3

Reactant 2

HCID 616604Ethyl p-(2-oxo-1,3-oxazolidin-3-yl)benzoateHCID 584847031-(2,6-Dimethylpyridin-3-yl)piperazine

Product 1

HCID 584848113-{4-[4-(2,6-Dimethylpyridin-3-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneYield 15.8%

Procedure

By reaction and treatment in the same manner as in Example 34 and using ethyl 4-(2-oxooxazolidin-3-yl)benzoate (353 mg) described in Preparation Example 12 and 1-(2,6-dimethylpyridin-3-yl)piperazine (287 mg) described in Preparation Example 153, the title compound (90.2 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 34
  2. customdescribed in Preparation Example 153

Sources & evidence

ORD record
ord-2f016fdd0c174f72b85a00e4faed29d4
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Linked notes

Loading…