4-Methoxyphenethyl alcohol → 4-[2-(4-Methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid
Reaction equation
[CH:1]1([CH2:5][O:6][C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH:9]=[C:10]([C:16]([OH:18])=[O:17])[NH:11]3)[CH2:4][CH2:3][CH2:2]1.[CH3:19][O:20][C:21]1C=CC(CCO)=[CH:23][CH:22]=1.C(OC(C1NC2C(C=1)=C(O)C=CC=2)=O)C>>[CH3:19][O:20][C:21]1[CH:2]=[CH:3][C:4]([CH2:1][CH2:5][O:6][C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH:9]=[C:10]([C:16]([OH:18])=[O:17])[NH:11]3)=[CH:23][CH:22]=1Participants
4
Procedure
4-[2-(4-Methoxy-phenyl)-ethoxy]-1H-indole-2-carboxylic acid (16l) is synthesized analogous to 16a from 2-(4-methoxy-phenyl)-ethanol and 4-hydroxy-1H-indole-2-carboxylic acid ethyl ester.