Dimethyl Sulfoxide → 4-(7-Methoxy-2-pyridin-2-yl-quinolin-4-yloxy)-pyrrolidine-1,2-dicarboxylic Acid 1-tert-butyl Ester

HRID 180616

Reaction equation

HRID 180616 reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH:9]([C:10](=[O:11])[OH:12])[CH2:13][CH:14]([OH:16])[CH2:15]1.[CH3:17][C:18]([CH3:19])([O-:20])[CH3:21].[CH3:42][S:43]([CH3:44])=[O:45].[Cl:23][c:24]1[cH:25][c:26](-[c:36]2[n:37][cH:38][cH:39][cH:40][cH:41]2)[n:27][c:28]2[cH:29][c:30]([O:34][CH3:35])[cH:31][cH:32][c:33]12.[K+:22].[OH2:46]>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH:9]([C:10](=[O:11])[OH:12])[CH2:13][CH:14]([O:16][c:24]2[cH:25][c:26](-[c:36]3[n:37][cH:38][cH:39][cH:40][cH:41]3)[n:27][c:28]3[cH:29][c:30]([O:34][CH3:35])[cH:31][cH:32][c:33]23)[CH2:15]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium CationHCID 962WaterHCID 3352551-((Tert-butoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acidHCID 45749132-Methylpropan-2-olateHCID 222502394-Chloro-7-methoxy-2-(pyridin-2-yl)quinoline

Product 1

HCID 207736124-(7-Methoxy-2-pyridin-2-yl-quinolin-4-yloxy)-pyrrolidine-1,2-dicarboxylic Acid 1-tert-butyl Ester

Sources & evidence

ORD record
ord-ccc38fcf846f4f01b8d1dc427366cd76
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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