Thionyl Chloride → 4-Chloro-1-(chloromethyl)-2-methoxybenzene

HRID 1806790

Reaction equation

[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]O)=[C:4]([O:10][CH3:11])[CH:3]=1.S(Cl)([Cl:14])=O>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][Cl:14])=[C:4]([O:10][CH3:11])[CH:3]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 35493934 Chloro-2-methoxybenzyl alcohol

Product 1

HCID 185235604-Chloro-1-(chloromethyl)-2-methoxybenzeneYield 95%

Procedure

Step A In a manner similar to the method described in Example 57 Step A, 4-chloro-2-methoxybenzyl alcohol (Aldrich) (4.9 g, 28 mmol) was reacted with thionyl chloride (20 mL) to give 4-chloro-2-methoxybenzyl chloride as a white solid (5.1 g, 95%).

Sources & evidence

ORD record: ord-df22fcf813f049ad88970e596e1a4c2e
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08354444B2

Linked notes

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