Thiomorpholine-4-carbonyl chloride → 6-Fluoro-1-(thiomorpholine-4-carbonyl)-1H-indazol-3-yl thiomorpholine-4-carboxylate

Reaction equation

[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([OH:11])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[N:12]1([C:18](Cl)=[O:19])[CH2:17][CH2:16][S:15][CH2:14][CH2:13]1>>[N:12]1([C:18]([O:11][C:6]2[C:5]3[C:9](=[CH:10][C:2]([F:1])=[CH:3][CH:4]=3)[N:8]([C:18]([N:12]3[CH2:17][CH2:16][S:15][CH2:14][CH2:13]3)=[O:19])[N:7]=2)=[O:19])[CH2:17][CH2:16][S:15][CH2:14][CH2:13]1

Participants

Reactant 2

HCID 19080217Thiomorpholine-4-carbonyl chloride

HCID 178518961HCID 178518961, compound

Product 1

HCID 684595896-Fluoro-1-(thiomorpholine-4-carbonyl)-1H-indazol-3-yl thiomorpholine-4-carboxylate

Procedure

In analogy to example 1, 200 mg (1.315 mmol) of 6-fluoro-1H-indazol-3-ol were reacted with 261.4 mg (1.578 mmol) of thiomorpholine-4-carbonyl chloride.

Sources & evidence

ORD record: ord-7341ceb779c74120a2ac13a0749c6e63
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08357698B2

Reaction notes

Loading…