Ammonia → HCID 57417080, compound
Reaction equation
C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([N:10]([CH3:12])[CH3:11])[CH2:7][NH:6]1)=O.[NH3:13]>CO>[CH3:11][N:10]([CH3:12])[C@H:8]1[CH2:7][NH:6][C@H:5]([C:3]([NH2:13])=[O:2])[CH2:9]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of (2S,4R)-4-dimethylamino-pyrrolidine-2-carboxylic acid methyl ester (Stage B.1, 225 mg) and 7 M ammonia in MeOH (7 mL) was stood for 18 h at it in a sealed vessel. Evaporation and trituration with Et2O gave the title compound as a white solid.
Workup
- customEvaporation and trituration with Et2O
Sources & evidence
- ORD record
- ord-d707340548c94d08856d387734c34a6d
- Source dataset
- uspto-grants-2013_01
- Patent number
- US08357707B2
Reaction notes
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