Ammonia → 1-Cbz-(S)-azetidine-2-carboxamide
Reaction equation
C[O:2][C:3]([C@@H:5]1[CH2:8][CH2:7][N:6]1[C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])=O.[NH3:19]>CO>[CH2:12]([O:11][C:9]([N:6]1[CH2:7][CH2:8][C@H:5]1[C:3](=[O:2])[NH2:19])=[O:10])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of (S)-azetidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (2.5 g) and 7 M ammonia in MeOH (10 ml) was stood at it for 18 h in a sealed vessel. The RM was then evaporated to give the title compound as a white solid which was used without further purification. MS: M+H 235.1 and M−H 233.1.
Workup
- customThe RM was then evaporated
Sources & evidence
- ORD record
- ord-9db8f77e0b28488caa7e42165a1c925d
- Source dataset
- uspto-grants-2013_01
- Patent number
- US08357707B2
Reaction notes
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