Phosphorus oxide (P4O10) → 3,3,3-Trifluoro-2,2-dimethyl-propionitrile

Reaction equation

[F:1][C:2]([F:10])([F:9])[C:3]([CH3:8])([CH3:7])[C:4]([NH2:6])=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[F:1][C:2]([F:10])([F:9])[C:3]([CH3:8])([CH3:7])[C:4]#[N:6]

Participants

Reactant 2

HCID 14812Phosphorus oxide (P4O10)

HCID 575162793,3,3-Trifluoro-2,2-dimethyl-propionamide

Product 1

HCID 207676543,3,3-Trifluoro-2,2-dimethyl-propionitrile

Conditions

Temperature: 200 °C

Procedure

A mixture of 3,3,3-trifluoro-2,2-dimethyl-propionamide (Stage 44.4) (121.2 mmol) and phosphorus pentoxide (121.2 mmol) was slowly heated to 200° C. and the resulting distillate collected. The title compound was obtained as a colorless liquid.

Sources & evidence

ORD record: ord-361a407d862c4749a102d0c4ccf3caa6
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08357707B2

Reaction notes

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