HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate → (S)-2-([1,5]Naphthyridin-2-ylaminomethyl)-piperidine-1-carboxylic acid tert butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate | HCID 1502020 | — |
| Reactant | 2-Chloro-1,5-naphthyridine | HCID 15153031 | — |
| Product | (S)-2-([1,5]Naphthyridin-2-ylaminomethyl)-piperidine-1-carboxylic acid tert butyl ester | HCID 86593673 | — |
Reaction Steps
The title compound (0.48 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (0.59 g) and 2-chloro-1,5-naphthyridine Rapoport, et al J. Org. Chem. (1971), 36(3), 450-4 (0.40 g) according to the method of D30.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07741329B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-bce37ee91f1b41b695f60d5082862519 |
| Source note | uspto-grants-2010_06 |