Bromoacetone → 1,6-Dimethyl-8-oxo-7,8-dihydro-imidazo[1,2-a]pyrazin-1-ium bromide salt
Reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([NH2:9])=[O:8].[Br:10][CH2:11][C:12](=O)[CH3:13]>C(#N)C>[Br-:10].[CH3:1][N+:2]1[CH:6]=[CH:5][N:4]2[CH:11]=[C:12]([CH3:13])[NH:9][C:7](=[O:8])[C:3]=12Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
A mixture of 1-Methyl-1H-imidazole-2-carboxylic acid amide (3.0 g, 14.3 mmol), bromoacetone (2.36 g, 17.2 mmol) and acetonitrile (40 mL) is stirred overnight at 80° C. The solid formed is filtered and washed with acetonitrile to give 1,6-dimethyl-8-oxo-7,8-dihydro-imidazo[1,2-a]pyrazin-1-ium bromide salt (4.3 g, 86%).
Workup
- customThe solid formed
- filtrationis filtered
- washwashed with acetonitrile
Sources & evidence
- ORD record
- ord-d10cd3f347774ff1a7c89d2309ce0c33
- Source dataset
- uspto-grants-2013_01
- Patent number
- US08362018B2
Reaction notes
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