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2-[[(2,3-Difluorophenyl)methyl]thio]-4,6-pyrimidinediamine → 2-[[(2,3-Difluorophenyl)methyl]thio]-5-nitroso4,6-pyrimidinediamine

HRID 1814235
Notes
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Reaction equation

HRID 1814235 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10][C:11]1[N:16]=[C:15]([NH2:17])[CH:14]=[C:13]([NH2:18])[N:12]=1.[N:19]([O-])=[O:20].[Na+]>C(O)(=O)C.O>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10][C:11]1[N:12]=[C:13]([NH2:18])[C:14]([N:19]=[O:20])=[C:15]([NH2:17])[N:16]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 174102292-[[(2,3-Difluorophenyl)methyl]thio]-4,6-pyrimidinediamineHCID 23668193Sodium Nitrite

Product 1

HCID 222884992-[[(2,3-Difluorophenyl)methyl]thio]-5-nitroso4,6-pyrimidinediamineYield 153.7%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Conditions

Temperature
5 °C

Procedure

The product of step (a) (2.5 g) was dissolved in acetic acid (150 ml) and the solution cooled to 5° C. A solution of sodium nitrite (625 mg) in water (50 ml) was added dropwise resulting in a dark blue colouration. The reaction was stirred at room temperature for 30 minutes during which time a pink solid precipitated from solution. This was isolated by filtration and washed with water, then dried at 50° C. to give the sub-titled product as a blue solid (4.14 g)

Workup

  1. customresulting in a dark blue colouration
  2. customprecipitated from solution
  3. customThis was isolated by filtration
  4. washwashed with water
  5. customdried at 50° C.

Sources & evidence

ORD record
ord-48163b3cbeaf44deb6c54df8b2b2ae3c
Source dataset
uspto-grants-2005_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06875868B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes