1-Isopropylhydrazine hydrochloride → HCID 54535900, compound

Reaction equation

C[N:2]([CH:4]=[N:5][C:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-:15])=[O:14])C.Cl.[CH:18]([NH:21]N)([CH3:20])[CH3:19]>>[CH3:19][CH:18]([N:21]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N+:13]([O-:15])=[O:14])=[N:5][CH:4]=[N:2]1)[CH3:20]

Participants

Reactant 2

HCID 855731-Isopropylhydrazine hydrochloride

HCID 22493374HCID 22493374, compound

Product 1

HCID 54535900HCID 54535900, compound

Procedure

N-[(Dimethylamino)methylene]-2-nitrobenzamide, prepared in Example 90, and isopropylhydrazine hydrochloric acid salt were reacted as in Example 90 to give 1-(2-propyl)-5-(2-nitrophenyl)-1,2,4-triazole, which was reduced and coupled with CMI similarly to give the fumaric acid salt of N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(2-propyl-1H-1,2,4-triazol-5-yl)aniline.

Workup

customwere reacted as in Example 90

Sources & evidence

ORD record: ord-3c39c6dfd40842ae9dde7b7797a7ba0a
Source dataset: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06884801B1

Reaction notes

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