Hexane → HCID 57882275, compound
Reaction equation
[C:1]([C:3](=[CH:9][NH:10][C:11]1[CH:12]=[CH:13][C:14]2[S:18](=[O:20])(=[O:19])[CH2:17][CH2:16][C:15]=2[CH:21]=1)[C:4]([O:6]CC)=O)#[N:2].CCCCCC>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[O:6]=[C:4]1[C:21]2[C:11](=[CH:12][CH:13]=[C:14]3[S:18](=[O:19])(=[O:20])[CH2:17][CH2:16][C:15]3=2)[NH:10][CH:9]=[C:3]1[C:1]#[N:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 290 °C
Procedure
1.5 g (0.85 mmol) of ethyl 2-cyano-3-[(1,1-dioxido-2,3-dihydro-1-benzothien-5-yl)amino]acrylate were suspended in 15 ml of Dowtherm A and heated in a metal bath at 290° C. for about 1 h. The reaction mixture was then cooled to RT. The mixture was subsequently mixed with hexane and stirred at RT for 30 min; the precipitate produced thereby was filtered off with suction and washed with hexane. 836 mg (65%) of the desired product were obtained in the form of brownish crystals.