1-Cyclooct-2-enylethanol → HCID 66957734, compound
Reaction equation
[CH:1]1([CH:9]([OH:11])[CH3:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:3]=[CH:2]1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>ClCCl>[CH:1]1([C:9](=[O:11])[CH3:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:3]=[CH:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
At 0° C., a solution of 1-cyclooct-2-enylethanol (1.4 g, 9 mmol) in dichloromethane (20 ml) was added to pyridiniumchlorochromate (2.35 g, 11 mmol) in dichloromethane (30 ml). The resulting mixture was stirred at 20° C. during 3.5 h and filtered through Celitee ®. The filtrate was concentrated and the crude product purified by flash chromatography (hexane/Et2O 6:1) to give 0.7 g of 1-cyclooct-2-enylethanone (55%).
Workup
- filtrationfiltered through Celitee ®
- concentrationThe filtrate was concentrated
- customthe crude product purified by flash chromatography (hexane/Et2O 6:1)
Sources & evidence
- ORD record
- ord-45df2b171d9a41b1881ddfc9dcdf5963
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07605118B2
Reaction notes
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