2-Hydroxydiphenyl ether → 3-{2-Methyl-4-[3-(2-phenoxy-phenoxy)-phenoxy]-phenyl}-propionic acid

HRID 1822265Notes

Reaction equation

HRID 1822265 reaction equation
C[O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15](Br)[CH:14]=2)=[CH:8][C:7]=1[CH3:20].[O:22]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[OH:35])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH3:20][C:7]1[CH:8]=[C:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:35][C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[O:22][C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:14]=2)[CH:10]=[CH:11][C:6]=1[CH2:5][CH2:4][C:3]([OH:2])=[O:21]

Participants

3

Reactant 2

HCID 754912-Hydroxydiphenyl etherHCID 578941923-[4-(3-Bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester

Product 1

HCID 111549023-{2-Methyl-4-[3-(2-phenoxy-phenoxy)-phenoxy]-phenyl}-propionic acid

Procedure

The title compound is prepared by reacting the compound of 3-[4-(3-bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester with 2-phenoxy-phenol as in Example 18 to afford 0.106 g (42%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C28H24O5 440, found 441 (M+1).

Workup

  1. customto afford 0.106 g (42%)

Sources & evidence

ORD record
ord-bbb5588f6e33425e8f85ff4afa165d41
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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