Methyl 2-ethenyl-3-nitrobenzoate → HCID 22170201, compound
Reaction equation
[N+:1]([C:4]1[C:5]([CH:14]=[CH2:15])=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])([O-])=O>CCOC(C)=O.CCO.[Pd]>[NH2:1][C:4]1[C:5]([CH2:14][CH3:15])=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of methyl 3-nitro-2-vinylbenzoate (1.1 g, 5.31 mmol), and 5% Pd/C (100 mg) in EtOAc/EtOH 1:1 (50 ml) was hydrogenated at 3 atm over night. The mixture was filtered through Celite, and the filtrate was concentrated to give the title compound 0.93 g (97%) as a colourless oil.
Workup
- waitwas hydrogenated at 3 atm over night
- filtrationThe mixture was filtered through Celite
- concentrationthe filtrate was concentrated
Sources & evidence
- ORD record
- ord-70a7cb9a19d644eebe299f39c33200d8
- Source dataset
- uspto-grants-2006_05
- Patent number
- US07037925B2
Reaction notes
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