Dimethylamine → 1-[2-({2-[(6-Amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]-3-(dimethylamino)pyrrolidine-2,5-dione
Reaction equation
[CH3:1][NH:2][CH3:3].[NH2:4][C:5]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][NH:14][C:15]2[N:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=3[Cl:28])[C:18]([N:29]3[C:33](=[O:34])[CH:32]=[CH:31][C:30]3=[O:35])=[CH:17][N:16]=2)[CH:8]=[CH:7][C:6]=1[N+:36]([O-:38])=[O:37]>>[NH2:4][C:5]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][NH:14][C:15]2[N:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=3[Cl:28])[C:18]([N:29]3[C:33](=[O:34])[CH2:32][CH:31]([N:2]([CH3:3])[CH3:1])[C:30]3=[O:35])=[CH:17][N:16]=2)[CH:8]=[CH:7][C:6]=1[N+:36]([O-:38])=[O:37]Participants
3
Reactant 2
Product 1
Procedure
A large excess of dimethylamine was added to clean fractions of 1-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]-3-pyrroline-2,5-dione concentrated in vacuo.