4-Chlorobenzamidine → 2-(4-chloro-phenyl)-5-(3-chloro-thiophen-2-yl)-1H-imidazole

HRID 1823844

Reaction equation

HRID 1823844 reaction equation
Br[CH2:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][C:9]=1[Cl:10])=O.[Cl:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH2:18])=[NH:17])=[CH:14][CH:13]=1>C(Cl)(Cl)Cl>[Cl:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]2[NH:17][C:3]([C:5]3[S:6][CH:7]=[CH:8][C:9]=3[Cl:10])=[CH:2][N:18]=2)=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 2034374-ChlorobenzamidineHCID 27644982-Bromo-1-(3-chloro-2-thienyl)-1-ethanone

Product 1

HCID 221478732-(4-chloro-phenyl)-5-(3-chloro-thiophen-2-yl)-1H-imidazole

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Compounds of this invention with Formula IV may be prepared as illustrated by the exemplary reaction in Scheme 3. Reaction of 2-bromo-1-(3-chloro-thiophen-2-yl)-ethanone with 4-chloro-benzamidine in chloroform produces the product 2-(4-chloro-phenyl)-5-(3-chloro-thiophen-2-yl)-1H-imidazole.

Workup

  1. customas illustrated by the exemplary reaction in Scheme 3

Sources & evidence

ORD record
ord-192882aa987643eea4938325bb67510b
Source dataset
uspto-grants-2006_05
Patent number
US07041685B2

Linked notes

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