Toluene → 1-(4-Amino-2-methylsulfanyl-pyrimidin-5-yl)-ethanone

Reaction equation

[NH2:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1.[C:12]1(C)C=CC=CC=1>>[NH2:1][C:2]1[C:7]([C:8](=[O:9])[CH3:12])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1

Participants

Reactant 2

HCID 1140Toluene

HCID 220531[4-Amino-2-(methylsulfanyl)pyrimidin-5-yl]methanol

Product 1

HCID 111830131-(4-Amino-2-methylsulfanyl-pyrimidin-5-yl)-ethanoneYield 72%

Procedure

By substituting 1-(4-amino-2-methylsulfanyl-pyrimidin-5-yl)-ethanol (Example 34) for (4-amino-2-methylsulfanyl-pyrimidin-5-yl)-methanol in Example 3 and conducting the reaction at 80° C. in toluene, 3.74 g (72%) of the product as a solid is obtained.

Sources & evidence

ORD record: ord-17c280d8d11447929951c2603eef6d8b
Source dataset: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07053070B2

Reaction notes

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