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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 18266Generated: October 27, 2026

Ethyl indole-2-carboxylate → 4-fluoro-1-methyl-1H-indole-3-carbaldehyde

https://huagongshe.com/reaction/18266

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
Reactant4-Fluoro-1H-indole-3-carbaldehydeHCID 22139006—
Product4-fluoro-1-methyl-1H-indole-3-carbaldehydeHCID 2213899454%

Reaction Steps

According to the procedure of Preparation 9 (a), except substituting 4-fluoro-1H-indole-3-carboxaldehyde (0.41 g, 2.5 mmole) for the ethyl-indole-2-carboxylate, the title compound (0.24 g, 54%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07741339B2
Source datasetuspto-grants-2010_06
ORD IDord-d928788cda6740eb8747d4e943ef233e
Source noteuspto-grants-2010_06