p-Fluoronitrobenzene → 1-Nitro-4-{[4-(trifluoromethyl)benzyl]oxy}benzene

HRID 1827377

Reaction equation

HRID 1827377 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1.FC1C=CC([N+]([O-])=O)=CC=1.[F:29][C:30]([F:40])([F:39])C1C=CC(CO)=CC=1>CO>[F:29][C:30]([F:40])([F:39])[C:18]1[CH:17]=[CH:16][C:4]([CH2:5][O:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 9590p-FluoronitrobenzeneHCID 676844-(Trifluoromethyl)benzenemethanolHCID 22137915HCID 22137915, compound

Product 1

HCID 27437921-Nitro-4-{[4-(trifluoromethyl)benzyl]oxy}benzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared in analogy to 1-(3-fluorobenzyloxy)-4-nitro-benzene, starting from 4-fluoro nitrobenzene and 4-trifluoromethyl benzyl alcohol. Yield after recristallisation from methanol: 82% of a brownish solid. Mp=80.5-81.5° C.

Sources & evidence

ORD record
ord-846e9f81733d4d6183b4189cc4e4cbb9
Source dataset
uspto-grants-2006_05
Patent number
US07053245B2

Linked notes

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