2-Methyl-4-nitrophenol → 1-(3-Fluorobenzyloxy)-2-methyl-4-nitrobenzene

Reaction equation

[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16]Br>>[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16][O:11][C:3]1[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=1[CH3:1]

Participants

Reactant 2

HCID 74422-Methyl-4-nitrophenol

HCID 680073-Fluorobenzyl bromide

Product 1

HCID 221379601-(3-Fluorobenzyloxy)-2-methyl-4-nitrobenzeneYield 62%

Procedure

Prepared in analogy to example 8 from 2-methyl-4-nitrophenol and 3-fluoro-benzylbromide. Colorless oil. Yield=62%. MS: m/e=261.1 (M+).

Sources & evidence

ORD record: ord-0ae948e770fc4814bfa8ad82dc4b883e
Source dataset: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07053245B2

Reaction notes

Loading…