5-Methoxyindole-3-carbaldehyde → 5-methoxy-1-methyl-1H-indole-3-carbaldehyde

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH:12]=[O:13].[CH3:14]C1(C=O)C2C(=CC=CC=2)NC1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:14])[CH:7]=[C:6]2[CH:12]=[O:13]

Participants

Reactant 2

HCID 827585-Methoxyindole-3-carbaldehyde

HCID 221391183-methyl-1H-indole-3-carboxaldehyde

Product 1

HCID 9259735-methoxy-1-methyl-1H-indole-3-carbaldehydeYield 92%

Procedure

According to the procedure of Preparation 13 (a), except substituting 5-methoxy-1H-indole-3-carboxaldehyde for the 3-methyl-1H-indole-3-carboxaldehyde, the title compound (0.86 g, 92%) was obtained as a light tan solid: MS (ES) m/e 190.2 (M+H)+.

Sources & evidence

ORD record: ord-016afe0cdf3c4fc392b5782ab1e68d0b
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07741339B2

Reaction notes

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