4-Pyridinemethanamine → HCID 22053636, compound

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[C:18]([N:20]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][N:23]2[C:31]([C:34]([OH:36])=O)=[CH:32][CH:33]=[C:22]2[CH2:21]1)=[O:19].[NH2:37][CH2:38][C:39]1[CH:44]=[CH:43][N:42]=[CH:41][CH:40]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[C:18]([N:20]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][N:23]2[C:31]([C:34]([NH:37][CH2:38][C:39]3[CH:44]=[CH:43][N:42]=[CH:41][CH:40]=3)=[O:36])=[CH:32][CH:33]=[C:22]2[CH2:21]1)=[O:19]

Participants

Reactant 2

HCID 773174-Pyridinemethanamine

HCID 21947850HCID 21947850, compound

Product 1

HCID 22053636HCID 22053636, compound

Procedure

The title compound was prepared by the coupling the 10-[2-chloro-4-(naphthalen-1-yl)phenyl]carbonyl}-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxylic acid of Step C, with 4-(aminomethyl)pyridine (1.25 equiv) in the manner of Example 1, Step G.

Sources & evidence

ORD record: ord-050e20c85c8343adb1238a796495bba1
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07064120B2

Reaction notes

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