3-Formyl-2-methylindole → methyl 1-methyl-3-(methylaminomethyl)-1H-indole-7-carboxylate

HRID 18301

Reaction equation

HRID 18301 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:11]([O:13][CH3:14])=[O:12])[C:4]([CH:15]=O)=[CH:3]1.C[C:18]1[NH:19]C2C(C=1C=O)=CC=CC=2>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[C:11]([O:13][CH3:14])=[O:12])[C:4]([CH2:15][NH:19][CH3:18])=[CH:3]1

Participants

3

Reactant 2

HCID 731663-Formyl-2-methylindoleHCID 22139012Methyl 3-formyl-1-methylindole-7-carboxylate

Product 1

HCID 22139141methyl 1-methyl-3-(methylaminomethyl)-1H-indole-7-carboxylateYield 92%

Procedure

According to the procedure of Preparation 12, except substituting 1-methyl-7-methoxycarbonyl-1H-indole 3-carboxaldehyde for the 2-methylindole-3-carboxaldehyde, the title compound (1.7 g, 92%) was obtained as an oil: MS (ES) m/e 233.2 (M+H)+.

Workup

  1. customAccording to the procedure of Preparation 12

Sources & evidence

ORD record
ord-ef4a20eef7314d66a3e37f69970bbd2f
Source dataset
uspto-grants-2010_06
Patent number
US07741339B2

Linked notes

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