Ethyl indole-2-carboxylate → 6-methoxy-1-methyl-1H-indole

Reaction equation

[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][NH:9]2)=[CH:5][CH:4]=1.N1C2C(=CC=CC=2)C=[C:13]1C(OCC)=O>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[CH:8][N:9]2[CH3:13])=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 73125Ethyl indole-2-carboxylate

HCID 766596-Methoxy-1H-indole

Product 1

HCID 47779296-methoxy-1-methyl-1H-indoleYield 95%

Procedure

According to the procedure of Preparation 9 (a), except substituting 6-methoxy-1H-indole for the ethyl indole-2-carboxylate, the title compound (2.3 g, 95%) was obtained as an oil: MS (ES) m/e 162.2 (M+H)+.

Sources & evidence

ORD record: ord-7fed0579a32d43daaab0b280d92f1751
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07741339B2

Reaction notes

Loading…