Pyridine-2-carbothioamide → HCID 22049807, compound
Reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18](=[S:20])[NH2:19]>>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:19]=[C:18]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=2)[S:20][CH:2]=1Participants
3
Procedure
By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (446 mg) and pyridine-2-carbothioamide (157 mg), the title compound (67 mg) was obtained as pale-red powder crystals.
Workup
- customBy the reaction in the same manner as in Example 25-iii)
Sources & evidence
- ORD record
- ord-e4c35bb206df4686a5f5ff00e32ec609
- Source dataset
- uspto-grants-2006_06
- Patent number
- US07067537B2
Reaction notes
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