Thionicotinamide → HCID 22049723, compound

Reaction equation

Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[C:12]([NH2:20])(=[S:19])[C:13]1[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=1>>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:20]=[C:12]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[S:19][CH:2]=1

Participants

Reactant 2

HCID 737155Thionicotinamide

HCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 22049723HCID 22049723, compoundYield 39.5%

Procedure

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (432 mg) and thionicotinamide (152 mg), the title compound (110 mg) was obtained as colorless powder crystals.

Workup

customBy the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record: ord-8d9b41d4397d4d188d3dd4e000bc0f14
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067537B2

Reaction notes

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