4-Pyridinecarbothioamide → HCID 22049802, compound

Reaction equation

Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[C:12]([NH2:20])(=[S:19])[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1>>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:20]=[C:12]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[S:19][CH:2]=1

Participants

Reactant 2

HCID 27237884-Pyridinecarbothioamide

HCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 22049802HCID 22049802, compoundYield 27.5%

Procedure

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (428 mg) and thioisonicotinamide (153 mg), the title compound (77 mg) was obtained as colorless powder crystals.

Workup

customBy the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record: ord-505e4386fb5c46aeaba5b5a6854d97d2
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067537B2

Reaction notes

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