4-(Trifluoromethyl)pyridine-3-carbothioamide → HCID 22049737, compound
Reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]([Br:12])[CH:6]=1)=O.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:20]=[CH:19][N:18]=[CH:17][C:16]=1[C:21](=[S:23])[NH2:22]>>[Br:12][C:7]1[CH:6]=[C:5]([C:3]2[N:22]=[C:21]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][C:15]=3[C:14]([F:25])([F:13])[F:24])[S:23][CH:2]=2)[CH:10]=[CH:9][C:8]=1[F:11]Participants
3
Procedure
By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(3-bromo-4-fluorophenyl)ethanone (3.10 g) and 4-trifluoromethylpyridine-3-thiocarboxamide (1.87 g), the title compound (1.50 g) was obtained as brown needle crystals.
Workup
- customBy the reaction in the same manner as in Example 25-iii)
Sources & evidence
- ORD record
- ord-f602b7b88b024fa5843c47a68e206547