Benzyl 4-hydroxyphenyl ketone → Methyl-phenyl-carbamic Acid 4-phenylacetyl-phenyl Ester
Reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:9])=[CH:4][CH:3]=1.[CH3:17][N:18]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:19](Cl)=[O:20]>>[C:11]1([CH2:10][C:8]([C:5]2[CH:4]=[CH:3][C:2]([O:1][C:19](=[O:20])[N:18]([CH3:17])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:7][CH:6]=2)=[O:9])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1Participants
3
Procedure
The title product was prepared from benzyl 4-hydroxyphenyl ketone and N-methyl-N-phenylcarbamoyl chloride. The crude product was subjected to preparative HPLC (68%, light yellow oil). HPLC-MS: m/z=431.2 (M+1); Rt: 3.55 min.
Sources & evidence
- ORD record
- ord-003301af047944049c847ea369739124
- Source dataset
- uspto-grants-2006_06
- Patent number