Pyridine → 4-[5-(3-Difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-piperazine-1-carboxylic Acid tert-butyl Ester

HRID 183124

Reaction equation

HRID 183124 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([O:21][CH3:22])[cH:16][cH:17][c:18]([NH2:20])[cH:19]2)[CH2:12][CH2:13]1.[F:28][CH:29]([O:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)[F:37].[S:23](=[O:24])(=[O:25])([Cl:26])[Cl:27].[cH:38]1[cH:39][cH:40][n:41][cH:42][cH:43]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([O:21][CH3:22])[cH:16][cH:17][c:18]([NH:20][S:23](=[O:24])(=[O:25])[c:35]3[cH:34][cH:33][cH:32][c:31]([O:30][CH:29]([F:28])[F:37])[cH:36]3)[cH:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 24648Sulfuryl chlorideHCID 68015(Difluoromethoxy)benzeneHCID 10686178Tert-butyl 4-(5-amino-2-methoxyphenyl)piperazine-1-carboxylate

Product 1

HCID 576995064-[5-(3-Difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-piperazine-1-carboxylic Acid tert-butyl Ester

Sources & evidence

ORD record
ord-baf4bd18c164437080e718dba3203b75
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

Loading…