1-Benzylpiperazine → HCID 69519493, compound

HRID 1831263

Reaction equation

HRID 1831263 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[C:17]([Cl:18])=[CH:16][C:15]([C:19]([F:22])([F:21])[F:20])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].[CH2:23]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[Cl:18][C:17]1[C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:33]3[CH2:34][CH2:35][N:30]([CH2:23][C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH2:31][CH2:32]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:16]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 220476914-(3-Chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

Product 1

HCID 69519493HCID 69519493, compound

Procedure

The hydrochloride of the title compound was prepared from 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-benzyl-piperazine, yield 94%. White crystals; m.p. 111–113° C. (resolidifies) and 114–115° C.; HPLC-MS m/z=492 (M+H).

Workup

  1. customm.p. 111–113° C. (resolidifies) and 114–115° C.

Sources & evidence

ORD record
ord-fe8cdf68122040a3b3c18844b8482f39
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Linked notes

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