5-Methyl-3-phenylisoxazole-4-carbonyl chloride → 4-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl)-1-phenylbutyl 5-methyl-3-phenyl-4-isoxazolecarboxylate

HRID 1832463

Reaction equation

HRID 1832463 reaction equation
[OH:1][CH:2]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:13]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[CH:15]=[CH:16][CH:17]=2)[CH2:8][CH2:7]1.[CH3:30][C:31]1[O:35][N:34]=[C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:32]=1[C:42](Cl)=[O:43]>>[CH3:30][C:31]1[O:35][N:34]=[C:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:32]=1[C:42]([O:1][CH:2]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([NH:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[CH:13]=2)[CH2:10][CH2:11]1)=[O:43]

Participants

3

Reactant 2

HCID 856245-Methyl-3-phenylisoxazole-4-carbonyl chlorideHCID 22048814N-(3-[1-(4-hydroxy-4-phenylbutyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Product 1

HCID 207230154-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl)-1-phenylbutyl 5-methyl-3-phenyl-4-isoxazolecarboxylate

Procedure

Prepared by Procedure Q1 and Scheme C2 (TEA) using N-{3-[1-(4-hydroxy-4-phenylbutyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 5-methyl-3-phenyl-4-isoxazolecarbonyl chloride: ESMS m/e: 580.0 (M+H)+.

Workup

  1. customPrepared by Procedure Q1 and Scheme C2 (TEA)

Sources & evidence

ORD record
ord-a522a95f6a674d4f84f26f850922663d
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Linked notes

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