2,4,5-Trifluorophenol → 1-{[(2R)-3-chloro-2-methylpropyl]oxy}-2,4,5-trifluorobenzene

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[OH:10].Br[CH2:12][C@@H:13]([CH3:16])[CH2:14][Cl:15]>>[Cl:15][CH2:14][C@H:13]([CH3:16])[CH2:12][O:10][C:3]1[CH:4]=[C:5]([F:9])[C:6]([F:8])=[CH:7][C:2]=1[F:1]

Participants

Reactant 2

HCID 1231532,4,5-Trifluorophenol

HCID 5479122(2S)-1-bromo-3-chloro-2-methylpropane

Product 1

HCID 695238651-{[(2R)-3-chloro-2-methylpropyl]oxy}-2,4,5-trifluorobenzene

Procedure

Prepared by Procedure U and Scheme AK using 2,4,5-trifluorophenol and (2S)-1-bromo-3-chloro-2-methylpropane.

Workup

customPrepared by Procedure U and Scheme AK

Sources & evidence

ORD record: ord-d768b9f357aa4624af5fe979f6d4fb8d
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067534B1

Reaction notes

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