Hydrazine, 1-naphthalenyl-, hydrochloride (1:1) → 2-Methyl-N-(3-{1-[2-(2-phenyl-1H-benzo[G]indol-3-YL)ethyl]-4-piperidinyl}phenyl)propanamide

HRID 1832585

Reaction equation

[CH3:1][CH:2]([CH3:29])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][C:21](=O)[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4].Cl.[C:31]1([NH:41]N)[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:34]=[CH:33][CH:32]=1>>[CH3:1][CH:2]([CH3:29])[C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]3[C:32]4[C:31](=[C:40]5[CH:39]=[CH:38][CH:37]=[CH:36][C:35]5=[CH:34][CH:33]=4)[NH:41][C:21]=3[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:14][CH2:13]2)[CH:7]=1)=[O:4]

Participants

Reactant 2

HCID 519949Hydrazine, 1-naphthalenyl-, hydrochloride (1:1)

HCID 220490202-methyl-N-{3-[1-(4-oxo-4-phenylbutyl)-4-piperidinyl]phenyl}propanamide

Product 1

HCID 220487742-Methyl-N-(3-{1-[2-(2-phenyl-1H-benzo[G]indol-3-YL)ethyl]-4-piperidinyl}phenyl)propanamide

Procedure

Prepared by Procedure E and Scheme M using 2-methyl-N-{3-[1-(4-oxo-4-phenylbutyl)-4-piperidinyl]phenyl}propanamide and 1-(1-naphthyl)hydrazine hydrochloride: ESMS m/e: 516.4 (M+H)+.

Workup

customPrepared by Procedure E and Scheme M

Sources & evidence

ORD record: ord-56bb51aadb1c4f1eb484a301ec03cd9e
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067534B1

Linked notes

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