N-[3-(4-Piperidinyl)phenyl]cyclopropanecarboxamide → N-(3-{1-[5-(3-Fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)cyclopropanecarboxamide

HRID 1832698

Reaction equation

HRID 1832698 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[CH:9]=1)=[O:7].[NH:15]1[CH2:20][CH2:19][CH:18]([C:21]2[CH:22]=[C:23]([NH:27][C:28]([CH:30]3[CH2:32][CH2:31]3)=[O:29])[CH:24]=[CH:25][CH:26]=2)[CH2:17][CH2:16]1>>[F:14][C:10]1[CH:9]=[C:8]([C:6](=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2][N:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:22]=[C:23]([NH:27][C:28]([CH:30]4[CH2:31][CH2:32]4)=[O:29])[CH:24]=[CH:25][CH:26]=3)[CH2:17][CH2:16]2)[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 22048669N-[3-(4-Piperidinyl)phenyl]cyclopropanecarboxamideHCID 220491125-Chloro-1-(3-fluorophenyl)-1-oxopentane

Product 1

HCID 22049504N-(3-{1-[5-(3-Fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)cyclopropanecarboxamide

Procedure

Prepared by Procedure K and Scheme B1 using 5-chloro-1-(3-fluorophenyl)-1-pentanone and N-[3-(4-piperidinyl)phenyl]cyclopropanecarboxamide: ESMS m/e: 423.2 (M+H)+.

Workup

  1. customPrepared by Procedure K and Scheme B1

Sources & evidence

ORD record
ord-3ebad7862a2540d48b9964e158d865f6
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Linked notes

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