1,1'-Biphenyl, 2-iodo- → N-(3-{1-[(1-[1,1'-Biphenyl]-2-YL-1H-indol-5-YL)methyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 1832997

Reaction equation

HRID 1832997 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[NH:14]1[C:22]2[C:17](=[CH:18][C:19]([CH2:23][N:24]3[CH2:29][CH2:28][CH:27]([C:30]4[CH:31]=[C:32]([NH:36][C:37](=[O:41])[CH:38]([CH3:40])[CH3:39])[CH:33]=[CH:34][CH:35]=4)[CH2:26][CH2:25]3)=[CH:20][CH:21]=2)[CH:16]=[CH:15]1>>[C:3]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:14]1[C:22]2[C:17](=[CH:18][C:19]([CH2:23][N:24]3[CH2:29][CH2:28][CH:27]([C:30]4[CH:31]=[C:32]([NH:36][C:37](=[O:41])[CH:38]([CH3:39])[CH3:40])[CH:33]=[CH:34][CH:35]=4)[CH2:26][CH2:25]3)=[CH:20][CH:21]=2)[CH:16]=[CH:15]1

Participants

3

Reactant 2

HCID 750251,1'-Biphenyl, 2-iodo-HCID 22049334N-{3-[1-(1H-indol-5-ylmethyl)-4-piperidinyl]phenyl)-2-methylpropanamide

Product 1

HCID 22048809N-(3-{1-[(1-[1,1'-Biphenyl]-2-YL-1H-indol-5-YL)methyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure C and Scheme Q1, with CuBr in place of Cu, using 2-iodo-1,1′-biphenyl and N-{3-[1-(1H-indol-5-ylmethyl)-4-piperidinyl]phenyl}-2-methylpropanamide: ESMS m/e: 528.3 (M+H)+.

Sources & evidence

ORD record
ord-570457e6544e454293de4c37e5a56cd9
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Linked notes

Loading…