Acetamidine monohydrochloride → HCID 54283790, compound

HRID 1833287

Reaction equation

HRID 1833287 reaction equation
CO[C:3]([P:5](=[O:12])([O:9][CH2:10][CH3:11])[O:6][CH2:7][CH3:8])=[O:4].Cl.[C:14]([NH2:17])(=[NH:16])[CH3:15]>O1CCCC1>[NH2:17][C:14](=[N:16][C:3]([P:5](=[O:12])([O:6][CH2:7][CH3:8])[O:9][CH2:10][CH3:11])=[O:4])[CH3:15]

Participants

4

Reactant 2

HCID 67170Acetamidine monohydrochlorideHCID 170573Phosphinecarboxylic acid, 1,1-diethoxy-, methyl ester, 1-oxide

Product 1

HCID 54283790HCID 54283790, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 98 parts of diethyl methoxycarbonylphosphonate plus 47 parts of acetamidine hydrochloride in 1000 parts of anhydrous tetrahydrofuran can be refluxed for 8 hours and the solvent then removed under reduced pressure to give diethyl 1-amino-1-methylmethyleneaminocarbonylphosphonate. In a similar manner, starting with the appropriate alkoxycarbonylphosphonate and imino compounds, the following compounds can be prepared:

Workup

  1. customthe solvent then removed under reduced pressure

Sources & evidence

ORD record
ord-86fc9fb571a944cbafec8910d46961a9
Source dataset
uspto-grants-1978_01
Patent number
US04066434

Linked notes

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