Formaldehyde → 3-(Hydroxymethyl)-4-methylpent-4-en-2-one

Reaction equation

[O:1]=[C:2]([CH:4]=[C:5]([CH3:7])[CH3:6])[CH3:3].[CH2:8]=[O:9]>>[CH3:6][C:5]([CH:4]([CH2:8][OH:9])[C:2](=[O:1])[CH3:3])=[CH2:7]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 8858Mesityl oxide

Product 1

HCID 141866443-(Hydroxymethyl)-4-methylpent-4-en-2-one

Procedure

The reaction is carried out at temperatures between 20° and 130° C. The reaction time is, for example, 3 hours at 30° C and a few minutes at 100° C. Advantageously, the mesityl oxide and catalyst are initially introduced and formaldehyde is metered in. The 2-methyl-3-hydroxymethyl-pent-1-en-4-one can be isolated from the reaction mixture by, for example, distillation, advantageously after neutralising the basic catalyst.

Workup

customis carried out at temperatures between 20° and 130° C
customis, for example, 3 hours at 30° C and a few minutes at 100° C

Sources & evidence

ORD record: ord-3faeea22ff9d4aed965cd4e97dc45972
Source dataset: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04069257

Reaction notes

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