Ethyl isothiocyanate → HCID 178464567, compound

HRID 1834581

Reaction equation

N1C=CC(CNCCN)=N1.C(N=C=S)C.[CH2:16]([NH:18][C:19]([NH:21][CH2:22][CH2:23][NH:24][CH2:25][C:26]1[CH:30]=[CH:29][NH:28][N:27]=1)=S)[CH3:17].[N:31]#[C:32][NH2:33].[Pb]>>[C:32]([NH:33][C:19]([NH:18][CH2:16][CH3:17])=[N:21][CH2:22][CH2:23][NH:24][CH2:25][C:26]1[CH:30]=[CH:29][NH:28][N:27]=1)#[N:31]

Participants

Reactant 4

HCID 10966Ethyl isothiocyanate

HCID 22262466CH2N2Pb

HCID 178465515HCID 178465515, compound

HCID 178511340HCID 178511340, compound

Product 1

HCID 178464567HCID 178464567, compound

Procedure

By the procedure of Example 3(b), reacting N-(3-pyrazolylmethyl)ethylenediamine with ethyl isothiocyanate, then reacting the resulting N-ethyl-N'-[2-(3-pyrazolylmethylamino)ethyl]thiourea with lead cyanamide gives N-cyano-N'-ethyl-N"-[2-(3-pyrazolylmethylamino)ethyl]guanidine. By the same procedure, using propyl isothiocyanate the corresponding N'-propyl compound is prepared. Also, by the same procedure, using 2-dimethylaminoethyl isothiocyanate, the product is N-cyano-N'-(2-dimethylaminoethyl)-N"-[2-(3-pyrazolymethylamino)ethyl]-guanidine.

Sources & evidence

ORD record: ord-ccf75bcf1c31415da2d24cec4a92db9b
Source dataset: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04070475

Linked notes

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