3-(3-Nitro-phenyl)-acrylonitrile → HCID 22186098, compound

HRID 1837516

Reaction equation

HRID 1837516 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]#[N:13])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]>C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Cl-].[Rh].C1C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]#[N:13])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 1

HCID 556693-(3-Nitro-phenyl)-acrylonitrile

Product 1

HCID 22186098HCID 22186098, compound

Reagents, catalysts & solvents 2

HCID 84599Chlorotris(triphenylphosphine)rhodium(I)CatalystHCID 241BenzeneSolvent

Conditions

Temperature
40 °C

Procedure

There are introduced into a cylinder 3 g of the product obtained in Step 1, 1.59 g of tris(triphenylphosphine)rhodium(I) chloride and 90 ml of benzene. The whole is heated for 5 hours at 40° C. under a hydrogen pressure of 5 bar. The solvent is evaporated off and the residue is purified by chromatography on silica gel using dichloromethane as eluant.

Workup

  1. customThe solvent is evaporated off
  2. customthe residue is purified by chromatography on silica gel

Sources & evidence

ORD record
ord-85e8aacf647b40d99e6441bc79a44ef9
Source dataset
uspto-grants-2004_08
Patent number
US06784183B2

Linked notes

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