Methyl iodide → 1-(3,5-Difluoro-2-methoxyphenyl)ethanone

HRID 1838752

Reaction equation

[CH3:1]I.[F:3][C:4]1[C:5]([OH:14])=[C:6]([C:11](=[O:13])[CH3:12])[CH:7]=[C:8]([F:10])[CH:9]=1>>[F:3][C:4]1[C:5]([O:14][CH3:1])=[C:6]([C:11](=[O:13])[CH3:12])[CH:7]=[C:8]([F:10])[CH:9]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 27369761-(3,5-Difluoro-2-hydroxyphenyl)ethan-1-one

Product 1

HCID 187554401-(3,5-Difluoro-2-methoxyphenyl)ethanone

Procedure

In an analogous manner to that described in (α) 1-(3,5-difluoro-2-hydroxy-phenyl)-ethanone was alkylated with methyliodide to yield 1-(3,5-difluoro-2-methoxy-phenyl)-ethanone as beige needles; MS: 186 (M)+.

Sources & evidence

ORD record: ord-18138f1cfbe844959652f548faf476a5
Source dataset: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06673931B2

Linked notes

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