Quinuclidine, 3-amino-, dihydrochloride → (Rs)-n-(1-azabicyclo[2.2.2]oct-3-yl)[e-3-(2-trifluoromethylphenyl)propenamide]

HRID 1840907Notes

Reaction equation

HRID 1840907 reaction equation
Cl.Cl.[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[CH:5]([NH2:11])[CH2:4]2.[F:12][C:13]([F:26])([F:25])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1/[CH:20]=[CH:21]/[C:22](O)=[O:23]>>[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[CH:5]([NH:11][C:22](=[O:23])/[CH:21]=[CH:20]/[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:13]([F:25])([F:26])[F:12])[CH2:4]2

Participants

3

Reactant 2

HCID 197853Quinuclidine, 3-amino-, dihydrochlorideHCID 7196252-(Trifluoromethyl)cinnamic acid, (E)-

Product 1

HCID 9945116(Rs)-n-(1-azabicyclo[2.2.2]oct-3-yl)[e-3-(2-trifluoromethylphenyl)propenamide]

Procedure

Prepared as a free base by a method analogous to that described in Example 1 from racemic 1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(2-trifluoromethylphenyl)propenoic acid; MS (ES+) 325 (MH+).

Workup

  1. customPrepared as a free base by a method analogous to

Sources & evidence

ORD record
ord-20d1366df0bf4007a0db4970cb2f3893
Source dataset
uspto-grants-2004_01
Patent number
US06683090B1

Reaction notes

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