3-Chlorophenylacetic acid → 2-[(3-Chlorophenyl)acetamido)butyric acid iso-butyl ester

HRID 1841153Notes

Reaction equation

HRID 1841153 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 158793-Chlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 155476412-[(3-Chlorophenyl)acetamido)butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 3-chlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-549a4dddf42c482093ebc228b1db7252
Source dataset
uspto-grants-2004_01
Patent number
US06683075B1

Reaction notes

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