(R)-Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one → HCID 71735413, compound
Reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C@@H:21]3[O:30][C:25]4=[N:26][CH:27]=[CH:28][CH:29]=[C:24]4[O:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.C1[C@H]2CNCCN2C(=O)O1>>[O:23]1[C:24]2[C:25](=[N:26][CH:27]=[CH:28][CH:29]=2)[O:30][C@@H:21]([C:18]2[CH:19]=[CH:20][C:15]([CH2:14][N:11]3[CH2:10][CH2:9][N:8]4[C:6](=[O:7])[O:5][CH2:1][C@H:13]4[CH2:12]3)=[CH:16][CH:17]=2)[CH2:22]1Participants
3
Procedure
Compound 285 is synthesized from Intermediate C and (R)-hexahydro-oxazolo[3,4-a]pyrazin-3-one according to General Method M. (LC/MS method 16: ES+ m/z 368.4 [M+H]+, Rt=2.52 min).
Sources & evidence
- ORD record
- ord-8d27429d664b43aca9febed19c43e633
- Source dataset
- uspto-grants-2015_02