Acetyl chloride → N-{[3-(2-{[(1-methylethyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)phenyl]methyl}acetamide

HRID 18430

Reaction equation

[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[CH2:14][CH:13]([NH:18][S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])[CH2:12]3)[CH:6]=[CH:7][CH:8]=1.[C:25](Cl)(=[O:27])[CH3:26]>>[CH3:23][CH:22]([S:19]([NH:18][CH:13]1[CH2:12][C:11]2[C:15](=[CH:16][CH:17]=[C:9]([C:5]3[CH:4]=[C:3]([CH2:2][NH:1][C:25](=[O:27])[CH3:26])[CH:8]=[CH:7][CH:6]=3)[CH:10]=2)[CH2:14]1)(=[O:21])=[O:20])[CH3:24]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 11515729N-{5-[3-(aminomethyl)phenyl]-2,3-dihydro-1H-inden-2-yl}-2-propanesulfonamide

Product 1

HCID 11639618N-{[3-(2-{[(1-methylethyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)phenyl]methyl}acetamide

Procedure

The title compound was prepared from N-{5-[3-(aminomethyl)phenyl]-2,3-dihydro-1H-inden-2-yl}-2-propanesulfonamide and acetyl chloride in a similar manner to Example 12.

Sources & evidence

ORD record: ord-d9589a36d332401ea4fed57d7b3c209b
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07741351B2

Linked notes

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