1-[3-(trifluoromethyl)benzyl]-1H-1,2,4-triazol-3-amine → [1-(3-Methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,4]triazol-3-yl]-amine

HRID 184392Notes

Reaction equation

HRID 184392 reaction equation
[CH3:1][c:2]1[n:3][s:4][c:5]([N:7]2[CH2:8][CH2:9][C:10](=[O:13])[CH2:11][CH2:12]2)[n:6]1.[F:14][C:15]([c:16]1[cH:17][c:18]([CH2:19][n:20]2[n:21][c:22]([NH2:25])[n:23][cH:24]2)[cH:26][cH:27][cH:28]1)([F:29])[F:30]>>[CH3:1][c:2]1[n:3][s:4][c:5]([N:7]2[CH2:8][CH2:9][CH:10]([NH:25][c:22]3[n:21][n:20]([CH2:19][c:18]4[cH:17][c:16]([C:15]([F:14])([F:29])[F:30])[cH:28][cH:27][cH:26]4)[cH:24][n:23]3)[CH2:11][CH2:12]2)[n:6]1

Participants

3

Reactant 2

HCID 70193291-[3-(trifluoromethyl)benzyl]-1H-1,2,4-triazol-3-amineHCID 592585101-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one

Product 1

HCID 53354730[1-(3-Methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,4]triazol-3-yl]-amine

Sources & evidence

ORD record
ord-816ecd53fdf44c1295ae89e8f840fc21
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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